Hemocompatible polymers for medical use


Polypropylene (PP) and polyethersulfone (PES) are commonly used as polymers that are dedicated to contact blood. PP is a material that builds blood collection devices and syringes. It is also applied to produce oxygenating membranes that are a significant part of cardiopulmonary bypass used during surgical procedures. PES builds membranes that can be also find in cardiopulmonary bypass, in dialyzers and other blood purification devices. Both PP and PES present acceptable hemocompatibility, yet after a long time of constant contact with blood they induce unwanted phenomena that are dangerous for patients. The presence of PP and PES in vivo results in blood proteins adsorption and platelets activation, macrophages activation and chronic inflammatory. Thus, to ensure that polymer membranes and devices would be able to work safely for a longer time, a suitable modification is needed in order to improve their hemocompatibility, especially adsorption of blood proteins (e.g. fibrinogen) and platelets activation, which lead to inflammation blood clots forming.

The project entails the development of materials with modified surface by hydrogel coating based on polyvinylpyrrolidone (PVP) and introduction of positive charge. Obtained materials according to assumptions will have antithrombogenic, biocompatible and hemocompatible properties. Purpose of planned study is determination: 1. how the change of the process parameters affects on the topography, thickness of the modified layer and content of functional group on the polymer surface 2. in vitro nontoxicity of the materials and the interaction of the obtained materials with blood in dynamic and static conditions, especially platelets activation and fibrinogen adsorption.

The project "Study on hemocompatibility of modified polymer surfaces" is a part of PRELUDIUM programme of National Science Centre, Poland, project no UMO-2014/15/N/ST8/02717.