PROJECT
The objective of the project is to develop a drug (isoprenaline) delivery wire preferably in form of drug eluting hydrogel coating with ultra-low friction interface for urological guide wire that would be pharmacologically active and able to actively and quickly relax tone of the ureter during surgical removal of renal stones. The urological guide wires are the most frequently used devices during endourological procedures. The innovative guide wire (IsoWire) will be characterized by a very low friction force in contact with ureteral tissue and controlled release of isoprenaline that is known to cause upper urinary tract relaxation. Temporary paralysis of ureteric muscles caused by isoprenaline activity will result in better drainage of irrigation fluid from the kidney and lowering of dangerous intrarenal pressures. The clinical use of IsoWire will result in the reduction of trauma to ureters associated with railroading instruments over the guide wire, reduction of complication rate associated with the procedure in particular intrarenal pressures and reduction in the overall cost of removal of kidney stones due to the elimination of the need for dilators and ability to perform treatment in a single session.
Project partners:
- Warsaw University of Technology,
- WISMED PL,
- University of Cape Town (South Africa).
