The process parameters impact on the surface pores size of the small diameter cylindrical polyurethane structures

PROJECT

The basis of the artificial blood vessel is cylindrical scaffold, which must fulfill certain characteristics - appropriate bio- and hemocompatibility. Additionally, the structure must have pores with appropriate size, primarily at the surface. The diameter of the surface pore adjusted to the size of the cell will help in faster integration with the surrounding tissue during the healing. Furthermore, a proper porosity ensures the exchange of gaseous substances and nutrients by the cell.

Aim of the presented research is obtaining small diameter cylindrical polyurethane structure with surface pores within the range of 8μm to 10μm. These structures will be prepared using the phase inversion method. It is planned to select the most favorable polyurethane concentrations, type of the non-solvent and process parameters for obtaining the desired structure. The materials biocompatibility as well as interaction with blood will be investigated.

Project “The process parameters impact on the surface pores size of the small diameter cylindrical polyurethane structures " is a part of PRELUDIUM program of National Science Centre, Poland, project no. 2016/21/N/ST8/01953.