Our team is working on the bioactive surfaces to promote surface endothelialization (colonization of biomaterial with endothelial cells). Under physiological conditions the process of blood clotting is controlled by endothelial cells. These cells constantly and actively prevent thrombosis by releasing a number of substances. Synthetic materials are not able to release certain substances due to limited capacity. Thus, the most promising strategy to fabricate non-thrombogenic materials is covering the implant surface with a layer of endothelial cells. This approach seems to be the most close to ideal, leading to hybrid implants - artificial devices coated with a layer of living cells permanently connected to the implant and actively prevent platelet activation and transplant rejection.

 The project is funded from Norway Grants in the Polish-Norwegian Research Programme operated by the National Centre for Research and Development.